THE 2-MINUTE RULE FOR PRO33

max in WT synaptoneurosomes, suggesting that Src signaling may very well be downregulated in KI synapses. On the other hand, our ability to rescue SERT function in KI midbrain synaptoneurosomes from the inhibition of FAK indicates elevated FAK signaling downstream from the Pro32Pro33 mutant, as confirmed by elevated pFAK localization in 5-HT synaps